Sunny Das

Introducing

Sunny Das

Postdoctoral Associate
Ph.D. Florida State University, USA
das@wi.mit.edu

Metastasis is responsible for the majority of carcinoma-associated deaths, yet no effective anti-metastatic therapies are currently available. This is due to a fragmentary understanding of molecular mechanisms underlying metastatic colonization of distant organs by disseminated tumor cells. Breast cancer-to-liver metastasis is associated with poor overall survival and prognosis. Using a combination of xenograft and syngeneic pre-clinical models, I aim to understand the nature of cancer cell-stromal crosstalk during the transition of recently extravasated breast cancer cells from initial dormancy/slow-proliferation to eventual metastatic colonization of the liver.

Publications

Zhang, Y., Donaher, J.L., Das, S. et al. Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis. Nat Cell Biol 24, 554–564 (2022).

Arthur W. Lambert, Christopher Fiore,
Yogesh Chutake, Robert A. Weinberg, et al. Quasi-mesenchymal cancer stem cells
(CSCs) are known to be highly metastatic. Developmental Cell. (2022).